Assay Detail
Functional
CHEMBL2395060
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Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 72 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and preliminary evaluation steroidal antiestrogen-geldanamycin conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.44 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278315 | GELDANAMYCIN | 2.0 | 1 | 8.01 |
| CHEMBL2391426 | — | — | 1 | 6.99 |
| CHEMBL2391427 | — | — | 1 | 5.94 |
| CHEMBL2391425 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278315 | GELDANAMYCIN | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL2391426 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL2391427 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL2391425 | — | IC50 | = | 15200.0 | nM | 4.82 |