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Assay Detail

CHEMBL2395269

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]Estradiol from human recombinant estrogen receptor alpha expressed in Sf9 cells after 2 hrs
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type Sf9
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Estrogen receptor (CHEMBL206)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Germain AR, Carmody LC, Nag PP, Morgan B, Verplank L, Fernandez C, Donckele E, Feng Y, Perez JR, Dandapani S, Palmer M, Lander ES, Gupta PB, Schreiber SL, Munoz B.
Bioorg Med Chem Lett (2013) 23 : 1834 -1838
PubMed 23403082 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 9.66 9.66
IC50 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL411 DIETHYLSTILBESTROL 4.0 2 9.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL411 DIETHYLSTILBESTROL Ki = 0.22 nM 9.66
CHEMBL411 DIETHYLSTILBESTROL IC50 = 0.77 nM -