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Assay Detail

CHEMBL2395286

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]Prazosin from alpha1B adrenergic receptor in Wistar rat liver after 60 mins
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Alpha-1B adrenergic receptor (CHEMBL315)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Germain AR, Carmody LC, Nag PP, Morgan B, Verplank L, Fernandez C, Donckele E, Feng Y, Perez JR, Dandapani S, Palmer M, Lander ES, Gupta PB, Schreiber SL, Munoz B.
Bioorg Med Chem Lett (2013) 23 : 1834 -1838
PubMed 23403082 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 9.82 9.82
IC50 1 9.57 9.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2 PRAZOSIN 4.0 2 9.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2 PRAZOSIN Ki = 0.15 nM 9.82
CHEMBL2 PRAZOSIN IC50 = 0.27 nM 9.57