Assay Detail
Functional
CHEMBL2395561
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Antagonist activity at human GPR55 expressed in CHO cells assessed as inhibition of lysophosphotidylinositol-induced beta-arrestin recruitment preincubated for 30 mins followed by lysophosphotidylinositol induction by beta-galactosidase reporter gene assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
8-Benzamidochromen-4-one-2-carboxylic acids: potent and selective agonists for the orphan G protein-coupled receptor GPR35.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.82 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2392183 | — | — | 1 | 5.21 |
| CHEMBL2392182 | — | — | 1 | 5.05 |
| CHEMBL2392179 | — | — | 1 | 4.66 |
| CHEMBL2392174 | — | — | 1 | 4.66 |
| CHEMBL2392151 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2392183 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL2392182 | — | IC50 | = | 8920.0 | nM | 5.05 |
| CHEMBL2392179 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL2392174 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL2392151 | — | IC50 | = | 29100.0 | nM | 4.54 |