Assay Detail
Binding
CHEMBL2395566
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Agonist activity at human GPR35b expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
8-Benzamidochromen-4-one-2-carboxylic acids: potent and selective agonists for the orphan G protein-coupled receptor GPR35.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.90 | 7.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2392179 | — | — | 1 | 7.83 |
| CHEMBL2392160 | — | — | 1 | 7.69 |
| CHEMBL2392174 | — | — | 1 | 7.66 |
| CHEMBL2392172 | — | — | 1 | 7.57 |
| CHEMBL2392167 | — | — | 1 | 7.54 |
| CHEMBL2392171 | — | — | 1 | 7.46 |
| CHEMBL2392170 | — | — | 1 | 7.39 |
| CHEMBL2392161 | — | — | 1 | 6.97 |
| CHEMBL2392178 | — | — | 1 | 6.89 |
| CHEMBL2392162 | — | — | 1 | 6.84 |
| CHEMBL2392157 | — | — | 1 | 6.33 |
| CHEMBL2392177 | — | — | 1 | 6.20 |
| CHEMBL2392158 | — | — | 1 | 6.17 |
| CHEMBL2392169 | — | — | 1 | 6.16 |
| CHEMBL2392159 | — | — | 1 | 6.06 |
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2392179 | — | EC50 | = | 14.7 | nM | 7.83 |
| CHEMBL2392160 | — | EC50 | = | 20.5 | nM | 7.69 |
| CHEMBL2392174 | — | EC50 | = | 22.1 | nM | 7.66 |
| CHEMBL2392172 | — | EC50 | = | 27.2 | nM | 7.57 |
| CHEMBL2392167 | — | EC50 | = | 28.6 | nM | 7.54 |
| CHEMBL2392171 | — | EC50 | = | 34.6 | nM | 7.46 |
| CHEMBL2392170 | — | EC50 | = | 40.5 | nM | 7.39 |
| CHEMBL2392161 | — | EC50 | = | 106.0 | nM | 6.97 |
| CHEMBL2392178 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL2392162 | — | EC50 | = | 143.0 | nM | 6.84 |
| CHEMBL2392157 | — | EC50 | = | 472.0 | nM | 6.33 |
| CHEMBL2392177 | — | EC50 | = | 628.0 | nM | 6.20 |
| CHEMBL2392158 | — | EC50 | = | 678.0 | nM | 6.17 |
| CHEMBL2392169 | — | EC50 | = | 699.0 | nM | 6.16 |
| CHEMBL2392159 | — | EC50 | = | 873.0 | nM | 6.06 |
| CHEMBL28079 | ZAPRINAST | EC50 | = | 2240.0 | nM | 5.65 |