Assay Detail
Binding
CHEMBL2395569
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Agonist activity at rat GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
G protein-coupled receptor GPR35 (CHEMBL2390812) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
8-Benzamidochromen-4-one-2-carboxylic acids: potent and selective agonists for the orphan G protein-coupled receptor GPR35.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 5.66 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | 7.21 |
| CHEMBL74 | CROMOLYN SODIUM | 4.0 | 1 | 6.01 |
| CHEMBL2392183 | — | — | 1 | 6.00 |
| CHEMBL2392176 | — | — | 1 | 5.96 |
| CHEMBL2392148 | — | — | 1 | 5.92 |
| CHEMBL2392177 | — | — | 1 | 5.89 |
| CHEMBL2392175 | — | — | 1 | 5.87 |
| CHEMBL2392174 | — | — | 1 | 5.85 |
| CHEMBL2392182 | — | — | 1 | 5.81 |
| CHEMBL2392162 | — | — | 1 | 5.75 |
| CHEMBL2392167 | — | — | 1 | 5.74 |
| CHEMBL2392178 | — | — | 1 | 5.69 |
| CHEMBL2392169 | — | — | 1 | 5.68 |
| CHEMBL2392165 | — | — | 1 | 5.68 |
| CHEMBL2392157 | — | — | 1 | 5.67 |
| CHEMBL2392173 | — | — | 1 | 5.65 |
| CHEMBL2392161 | — | — | 1 | 5.58 |
| CHEMBL2392168 | — | — | 1 | 5.56 |
| CHEMBL2392153 | — | — | 1 | 5.56 |
| CHEMBL2392164 | — | — | 1 | 5.55 |
| CHEMBL2392166 | — | — | 1 | 5.50 |
| CHEMBL2392159 | — | — | 1 | 5.50 |
| CHEMBL2392172 | — | — | 1 | 5.49 |
| CHEMBL2392181 | — | — | 1 | 5.44 |
| CHEMBL2392179 | — | — | 1 | 5.38 |
| CHEMBL2392147 | — | — | 1 | 5.18 |
| CHEMBL2392141 | — | — | 1 | 5.10 |
| CHEMBL299155 | TRANSTORINE | 1.0 | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28079 | ZAPRINAST | EC50 | = | 61.1 | nM | 7.21 |
| CHEMBL74 | CROMOLYN SODIUM | EC50 | = | 986.0 | nM | 6.01 |
| CHEMBL2392183 | — | EC50 | = | 991.0 | nM | 6.00 |
| CHEMBL2392176 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2392148 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2392177 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2392175 | — | EC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL2392174 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2392182 | — | EC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL2392162 | — | EC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL2392167 | — | EC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL2392178 | — | EC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL2392169 | — | EC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL2392165 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2392157 | — | EC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL2392173 | — | EC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL2392161 | — | EC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL2392168 | — | EC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL2392153 | — | EC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL2392164 | — | EC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL2392166 | — | EC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL2392159 | — | EC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL2392172 | — | EC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL2392181 | — | EC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL2392179 | — | EC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL2392147 | — | EC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL2392141 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL299155 | TRANSTORINE | EC50 | = | 66000.0 | nM | 4.18 |