Assay Detail
Binding
CHEMBL2395572
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Agonist activity at mouse GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
8-Benzamidochromen-4-one-2-carboxylic acids: potent and selective agonists for the orphan G protein-coupled receptor GPR35.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.35 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | 6.01 |
| CHEMBL2392151 | — | — | 1 | 5.52 |
| CHEMBL2392152 | — | — | 1 | 5.45 |
| CHEMBL74 | CROMOLYN SODIUM | 4.0 | 1 | 5.32 |
| CHEMBL2392183 | — | — | 1 | 5.30 |
| CHEMBL2392176 | — | — | 1 | 5.30 |
| CHEMBL2392157 | — | — | 1 | 5.30 |
| CHEMBL2392177 | — | — | 1 | 5.19 |
| CHEMBL2392141 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28079 | ZAPRINAST | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL2392151 | — | EC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL2392152 | — | EC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL74 | CROMOLYN SODIUM | EC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL2392183 | — | EC50 | = | 4980.0 | nM | 5.30 |
| CHEMBL2392176 | — | EC50 | = | 4950.0 | nM | 5.30 |
| CHEMBL2392157 | — | EC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL2392177 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL2392141 | — | EC50 | = | 17000.0 | nM | 4.77 |