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Assay Detail

CHEMBL2395575

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Binding
Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay
ChEMBL ↗
55
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

G-protein coupled receptor 35 (CHEMBL1293267) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

8-Benzamidochromen-4-one-2-carboxylic acids: potent and selective agonists for the orphan G protein-coupled receptor GPR35.
Funke M, Thimm D, Schiedel AC, Müller CE.
J Med Chem (2013) 56 : 5182 -5197
PubMed 23713606 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 55 6.48 7.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2392179 — — 2 7.96
CHEMBL2392174 — — 2 7.92
CHEMBL2392172 — — 2 7.81
CHEMBL2392171 — — 2 7.79
CHEMBL2392167 — — 2 7.78
CHEMBL2392160 — — 2 7.77
CHEMBL2392170 — — 1 7.60
CHEMBL2392141 — — 2 7.59
CHEMBL2392183 — — 2 7.52
CHEMBL177880 PAMOIC ACID — 1 7.30
CHEMBL2392178 — — 1 7.22
CHEMBL2392163 — — 1 6.95
CHEMBL2392162 — — 1 6.95
CHEMBL2392161 — — 1 6.93
CHEMBL2392182 — — 1 6.84
CHEMBL2392168 — — 1 6.52
CHEMBL2392157 — — 2 6.46
CHEMBL2392159 — — 1 6.42
CHEMBL2392173 — — 1 6.40
CHEMBL2392164 — — 1 6.37
CHEMBL2392177 — — 2 6.37
CHEMBL2392175 — — 1 6.20
CHEMBL2392158 — — 1 6.09
CHEMBL2392169 — — 1 6.08
CHEMBL2392165 — — 1 5.91
CHEMBL74 CROMOLYN SODIUM 4.0 1 5.90
CHEMBL2392152 — — 1 5.87
CHEMBL2392155 — — 1 5.86
CHEMBL2392176 — — 2 5.78
CHEMBL2392166 — — 1 5.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2392179 — EC50 = 11.1 nM 7.96
CHEMBL2392179 — EC50 = 11.22 nM 7.95
CHEMBL2392174 — EC50 = 12.02 nM 7.92
CHEMBL2392174 — EC50 = 12.1 nM 7.92
CHEMBL2392172 — EC50 = 15.4 nM 7.81
CHEMBL2392172 — EC50 = 15.49 nM 7.81
CHEMBL2392171 — EC50 = 16.4 nM 7.79
CHEMBL2392171 — EC50 = 16.22 nM 7.79
CHEMBL2392167 — EC50 = 16.8 nM 7.78
CHEMBL2392160 — EC50 = 16.98 nM 7.77
CHEMBL2392160 — EC50 = 17.0 nM 7.77
CHEMBL2392167 — EC50 = 16.98 nM 7.77
CHEMBL2392170 — EC50 = 25.1 nM 7.60
CHEMBL2392141 — EC50 = 25.7 nM 7.59
CHEMBL2392141 — EC50 = 26.0 nM 7.58
CHEMBL2392183 — EC50 = 30.5 nM 7.52
CHEMBL2392183 — EC50 = 30.2 nM 7.52
CHEMBL177880 PAMOIC ACID EC50 = 50.0 nM 7.30
CHEMBL2392178 — EC50 = 59.9 nM 7.22
CHEMBL2392162 — EC50 = 112.0 nM 6.95
CHEMBL2392163 — EC50 = 112.0 nM 6.95
CHEMBL2392161 — EC50 = 117.0 nM 6.93
CHEMBL2392182 — EC50 = 144.0 nM 6.84
CHEMBL2392168 — EC50 = 303.0 nM 6.52
CHEMBL2392157 — EC50 = 346.0 nM 6.46
CHEMBL2392157 — EC50 = 346.74 nM 6.46
CHEMBL2392159 — EC50 = 382.0 nM 6.42
CHEMBL2392173 — EC50 = 399.0 nM 6.40
CHEMBL2392177 — EC50 = 425.0 nM 6.37
CHEMBL2392164 — EC50 = 430.0 nM 6.37
CHEMBL2392177 — EC50 = 426.58 nM 6.37
CHEMBL2392175 — EC50 = 634.0 nM 6.20
CHEMBL2392158 — EC50 = 804.0 nM 6.09
CHEMBL2392169 — EC50 = 842.0 nM 6.08
CHEMBL2392165 — EC50 = 1220.0 nM 5.91
CHEMBL74 CROMOLYN SODIUM EC50 = 1260.0 nM 5.90
CHEMBL2392152 — EC50 = 1340.0 nM 5.87
CHEMBL2392155 — EC50 = 1380.0 nM 5.86
CHEMBL2392176 — EC50 = 1659.59 nM 5.78
CHEMBL2392176 — EC50 = 1660.0 nM 5.78
CHEMBL2392166 — EC50 = 1710.0 nM 5.77
CHEMBL28079 ZAPRINAST EC50 = 1960.0 nM 5.71
CHEMBL2392148 — EC50 = 4200.0 nM 5.38
CHEMBL2392151 — EC50 = 4670.0 nM 5.33
CHEMBL2392149 — EC50 = 4910.0 nM 5.31
CHEMBL2392153 — EC50 = 5440.0 nM 5.26
CHEMBL2392154 — EC50 = 6970.0 nM 5.16
CHEMBL2392150 — EC50 = 8960.0 nM 5.05
CHEMBL2392144 — EC50 = 12600.0 nM 4.90
CHEMBL2392146 — EC50 = 13400.0 nM 4.87