Assay Detail

CHEMBL2395712

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Binding

Binding affinity to adrenergic alpha1 receptor (unknown origin) by radioligand displacement assay

ChEMBL ↗

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Target

Adrenergic receptor alpha-1 (CHEMBL2094251) ↗

Open DB target context

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Adrenergic receptor alpha-1 (CHEMBL2094251) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Adrenergic receptor alpha-1

CHEMBL2094251

Anchored from Assay target.

Protein identity Adrenergic receptor alpha-1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	5 — Multiple protein complex / RNA
Curated By	Autocuration

Target

Adrenergic receptor alpha-1 (CHEMBL2094251) ↗

Type	PROTEIN FAMILY
Organism	Homo sapiens

Publication

Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.

Cappelli A, Manini M, Valenti S, Castriconi F, Giuliani G, Anzini M, Brogi S, Butini S, Gemma S, Campiani G, Giorgi G, Mennuni L, Lanza M, Giordani A, Caselli G, Letari O, Makovec F.
Eur J Med Chem (2013) 63 : 85 -94
PubMed 23466604 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	10.27	10.27
IC50	1	9.70	9.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2	PRAZOSIN	4.0	2	10.27

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2	PRAZOSIN	Ki	=	0.054	nM	10.27
CHEMBL2	PRAZOSIN	IC50	=	0.2	nM	9.70