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Assay Detail

CHEMBL2395738

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Functional
Cytotoxicity against human JURKAT-TALL cells after 48 hrs by Alamar Blue assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type JURKAT-TALL
Confidence 1 — Organism
Curated By Autocuration

Publication

Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: a structure-activity study.
Mott BT, He R, Chen X, Fox JM, Civin CI, Arav-Boger R, Posner GH.
Bioorg Med Chem (2013) 21 : 3702 -3707
PubMed 23673218 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.33 8.02

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 8.02
CHEMBL219245 1 7.00
CHEMBL2393389 1 6.82
CHEMBL2393396 1 6.66
CHEMBL2393392 1 6.54
CHEMBL2393391 1 6.53
CHEMBL2393390 1 6.29
CHEMBL2393395 1 5.76
CHEMBL2393397 1 5.71
CHEMBL207675 SODIUM ARESUNATE 1 5.16
CHEMBL2393393 1 5.13
CHEMBL566534 ARTEMETHER 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 9.6 nM 8.02
CHEMBL219245 IC50 = 100.0 nM 7.00
CHEMBL2393389 IC50 = 152.0 nM 6.82
CHEMBL2393396 IC50 = 220.0 nM 6.66
CHEMBL2393392 IC50 = 287.0 nM 6.54
CHEMBL2393391 IC50 = 296.0 nM 6.53
CHEMBL2393390 IC50 = 511.0 nM 6.29
CHEMBL2393395 IC50 = 1750.0 nM 5.76
CHEMBL2393397 IC50 = 1933.0 nM 5.71
CHEMBL207675 SODIUM ARESUNATE IC50 = 6887.0 nM 5.16
CHEMBL2393393 IC50 = 7436.0 nM 5.13
CHEMBL566534 ARTEMETHER IC50 > 30000.0 nM -