Assay Detail
Binding
CHEMBL2395763
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | J774 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.24 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2391055 | — | — | 1 | 8.66 |
| CHEMBL2391047 | — | — | 1 | 8.02 |
| CHEMBL2391054 | — | — | 1 | 7.89 |
| CHEMBL43366 | — | — | 1 | 7.54 |
| CHEMBL2391049 | — | — | 1 | 7.47 |
| CHEMBL289813 | — | — | 1 | 7.47 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.21 |
| CHEMBL2391048 | — | — | 1 | 7.16 |
| CHEMBL2391052 | — | — | 1 | 6.80 |
| CHEMBL2391053 | — | — | 1 | 6.72 |
| CHEMBL2391056 | — | — | 1 | 6.44 |
| CHEMBL2391050 | — | — | 1 | 6.44 |
| CHEMBL2391051 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2391055 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL2391047 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL2391054 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL43366 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2391049 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL289813 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL118 | CELECOXIB | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL2391048 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2391052 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2391053 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2391056 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2391050 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2391051 | — | IC50 | = | 440.0 | nM | 6.36 |