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Assay Detail

CHEMBL2395987

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Functional
Cytotoxicity against human HCT116 cells after 48 hrs by sulforhodamine B assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

Novel 3,5-bis(arylidene)-4-piperidone dimers: potent cytotoxins against colon cancer cells.
Das S, Das U, Michel D, Gorecki DK, Dimmock JR.
Eur J Med Chem (2013) 64 : 321 -328
PubMed 23644215 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 6.53 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2391208 1 7.70
CHEMBL2391212 1 7.70
CHEMBL2391219 1 7.70
CHEMBL2391207 1 7.70
CHEMBL2391205 1 7.52
CHEMBL2391209 1 7.52
CHEMBL2012925 1 7.40
CHEMBL2391214 1 7.30
CHEMBL2391217 1 7.22
CHEMBL2391204 1 7.05
CHEMBL2391218 1 6.75
CHEMBL2391210 1 6.57
CHEMBL2391213 1 6.39
CHEMBL2391216 1 6.22
CHEMBL2391222 1 6.17
CHEMBL2391221 1 6.14
CHEMBL185 FLUOROURACIL 4.0 1 5.34
CHEMBL140 CURCUMIN 3.0 1 4.94
CHEMBL2391206 1 4.70
CHEMBL2391215 1 4.57
CHEMBL2391211 1 4.56
CHEMBL2391220 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2391208 IC50 = 20.0 nM 7.70
CHEMBL2391212 IC50 = 20.0 nM 7.70
CHEMBL2391219 IC50 = 20.0 nM 7.70
CHEMBL2391207 IC50 = 20.0 nM 7.70
CHEMBL2391205 IC50 = 30.0 nM 7.52
CHEMBL2391209 IC50 = 30.0 nM 7.52
CHEMBL2012925 IC50 = 40.0 nM 7.40
CHEMBL2391214 IC50 = 50.0 nM 7.30
CHEMBL2391217 IC50 = 60.0 nM 7.22
CHEMBL2391204 IC50 = 90.0 nM 7.05
CHEMBL2391218 IC50 = 180.0 nM 6.75
CHEMBL2391210 IC50 = 270.0 nM 6.57
CHEMBL2391213 IC50 = 410.0 nM 6.39
CHEMBL2391216 IC50 = 600.0 nM 6.22
CHEMBL2391222 IC50 = 680.0 nM 6.17
CHEMBL2391221 IC50 = 720.0 nM 6.14
CHEMBL185 FLUOROURACIL IC50 = 4520.0 nM 5.34
CHEMBL140 CURCUMIN IC50 = 11540.0 nM 4.94
CHEMBL2391206 IC50 = 20050.0 nM 4.70
CHEMBL2391215 IC50 = 26730.0 nM 4.57
CHEMBL2391211 IC50 = 27370.0 nM 4.56
CHEMBL2391220 IC50 > 25000.0 nM -