Assay Detail

CHEMBL2396480

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Functional

Antiproliferative activity against human HT1080 cells after 96 hrs

ChEMBL ↗

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Target

HT-1080 (CHEMBL614580) ↗

Open DB target context

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HT-1080 (CHEMBL614580) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target HT-1080

CHEMBL614580

Anchored from Assay target.

Protein identity HT-1080

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HT-1080
Confidence	1 — Organism
Curated By	Autocuration

Target

HT-1080 (CHEMBL614580) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.

Gunzner-Toste J, Zhao G, Bauer P, Baumeister T, Buckmelter AJ, Caligiuri M, Clodfelter KH, Fu B, Han B, Ho YC, Kley N, Liang X, Liederer BM, Lin J, Mukadam S, O'Brien T, Oh A, Reynolds DJ, Sharma G, Skelton N, Smith CC, Sodhi J, Wang W, Wang Z, Xiao Y, Yuen PW, Zak M, Zhang L, Zheng X, Bair KW, Dragovich PS.
Bioorg Med Chem Lett (2013) 23 : 3531 -3538
PubMed 23668988 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.98	6.98

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2393183	—	—	1	6.98

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2393183	—	IC50	=	104.0	nM	6.98