Assay Detail
Functional
CHEMBL2398823
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Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-neuroinflammatory diarylheptanoids from the rhizomes of Dioscorea nipponica.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.62 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2398585 | — | — | 1 | 5.22 |
| CHEMBL2346808 | — | — | 1 | 5.11 |
| CHEMBL2398586 | — | — | 1 | 5.07 |
| CHEMBL475821 | — | — | 1 | 4.87 |
| CHEMBL2398587 | — | — | 1 | 4.84 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 4.74 |
| CHEMBL2398584 | — | — | 1 | 4.73 |
| CHEMBL2398583 | — | — | 1 | 4.42 |
| CHEMBL2398582 | — | — | 1 | 4.40 |
| CHEMBL2398581 | — | — | 1 | 4.34 |
| CHEMBL2398588 | — | — | 1 | 4.24 |
| CHEMBL464562 | — | — | 1 | 4.05 |
| CHEMBL2398580 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2398585 | — | IC50 | = | 5990.0 | nM | 5.22 |
| CHEMBL2346808 | — | IC50 | = | 7840.0 | nM | 5.11 |
| CHEMBL2398586 | — | IC50 | = | 8440.0 | nM | 5.07 |
| CHEMBL475821 | — | IC50 | = | 13360.0 | nM | 4.87 |
| CHEMBL2398587 | — | IC50 | = | 14360.0 | nM | 4.84 |
| CHEMBL256147 | TILARGININE | IC50 | = | 18260.0 | nM | 4.74 |
| CHEMBL2398584 | — | IC50 | = | 18580.0 | nM | 4.73 |
| CHEMBL2398583 | — | IC50 | = | 38110.0 | nM | 4.42 |
| CHEMBL2398582 | — | IC50 | = | 39670.0 | nM | 4.40 |
| CHEMBL2398581 | — | IC50 | = | 45920.0 | nM | 4.34 |
| CHEMBL2398588 | — | IC50 | = | 57050.0 | nM | 4.24 |
| CHEMBL464562 | — | IC50 | = | 89660.0 | nM | 4.05 |
| CHEMBL2398580 | — | IC50 | = | 95070.0 | nM | 4.02 |