Assay Detail
Functional
CHEMBL2399229
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Cytotoxicity against mcl-1 deficient MFF assessed as cell viability after overnight incubation by celltiter-blue assay in presence of 10% FBS
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.93 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 7.10 |
| CHEMBL2398252 | — | — | 1 | 6.07 |
| CHEMBL2398260 | — | — | 1 | 5.77 |
| CHEMBL2398173 | — | — | 1 | 5.72 |
| CHEMBL2398253 | — | — | 1 | 5.00 |
| CHEMBL2398250 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2398252 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL2398260 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2398173 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2398253 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2398250 | — | EC50 | > | 20000.0 | nM | - |