Assay Detail
Binding
CHEMBL2399233
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Binding affinity to human GST-tagged Bcl-Xl assessed as direct binding constant at steady state by surface plasmon resonance assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.10 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2398286 | — | — | 1 | 7.21 |
| CHEMBL371861 | — | — | 1 | 6.05 |
| CHEMBL2398292 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2398286 | — | Kd | = | 61.0 | nM | 7.21 |
| CHEMBL371861 | — | Kd | = | 900.0 | nM | 6.05 |
| CHEMBL2398292 | — | Kd | = | 9000.0 | nM | 5.05 |