Assay Detail
Binding
CHEMBL2399237
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Binding affinity to human GST-tagged Bcl-Xl by surface plasmon resonance assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.98 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2398260 | — | — | 1 | 7.89 |
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 7.85 |
| CHEMBL2398173 | — | — | 1 | 7.70 |
| CHEMBL2398263 | — | — | 1 | 7.39 |
| CHEMBL2398262 | — | — | 1 | 7.11 |
| CHEMBL2398249 | — | — | 1 | 7.06 |
| CHEMBL2398286 | — | — | 1 | 6.85 |
| CHEMBL2398170 | — | — | 1 | 6.12 |
| CHEMBL2398292 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2398260 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL376408 | ABT 737 | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2398173 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2398263 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2398262 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL2398249 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL2398286 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2398170 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL2398292 | — | IC50 | = | 15000.0 | nM | 4.82 |