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Assay Detail

CHEMBL2399337

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiprotozoal activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.
Patrick DA, Ismail MA, Arafa RK, Wenzler T, Zhu X, Pandharkar T, Jones SK, Werbovetz KA, Brun R, Boykin DW, Tidwell RR.
J Med Chem (2013) 56 : 5473 -5494
PubMed 23795673 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 41 7.24 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3216816 1 8.70
CHEMBL3215694 1 8.52
CHEMBL269671 ARTEMISININ 3.0 1 8.40
CHEMBL3217254 1 8.22
CHEMBL3215932 1 8.22
CHEMBL3217255 1 8.00
CHEMBL24057 FURAMIDINE -1.0 1 7.85
CHEMBL3216357 1 7.82
CHEMBL3215706 1 7.82
CHEMBL3216141 1 7.80
CHEMBL3215693 1 7.75
CHEMBL3215695 1 7.62
CHEMBL3216356 1 7.55
CHEMBL3215934 1 7.51
CHEMBL3216824 1 7.48
CHEMBL3216821 1 7.42
CHEMBL3217242 1 7.42
CHEMBL3216349 1 7.42
CHEMBL3215933 1 7.41
CHEMBL3216348 1 7.41
CHEMBL2398505 1 7.40
CHEMBL2398506 1 7.35
CHEMBL55 PENTAMIDINE 4.0 1 7.34
CHEMBL3215928 1 7.32
CHEMBL2398504 1 7.24
CHEMBL3215925 1 7.15
CHEMBL3217031 1 7.14
CHEMBL3216815 1 7.11
CHEMBL76 CHLOROQUINE 4.0 1 6.90
CHEMBL3217241 1 6.87

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3216816 IC50 = 2.0 nM 8.70
CHEMBL3215694 IC50 = 3.0 nM 8.52
CHEMBL269671 ARTEMISININ IC50 = 4.0 nM 8.40
CHEMBL3217254 IC50 = 6.0 nM 8.22
CHEMBL3215932 IC50 = 6.0 nM 8.22
CHEMBL3217255 IC50 = 10.0 nM 8.00
CHEMBL24057 FURAMIDINE IC50 = 14.0 nM 7.85
CHEMBL3215706 IC50 = 15.0 nM 7.82
CHEMBL3216357 IC50 = 15.0 nM 7.82
CHEMBL3216141 IC50 = 16.0 nM 7.80
CHEMBL3215693 IC50 = 18.0 nM 7.75
CHEMBL3215695 IC50 = 24.0 nM 7.62
CHEMBL3216356 IC50 = 28.0 nM 7.55
CHEMBL3215934 IC50 = 31.0 nM 7.51
CHEMBL3216824 IC50 = 33.0 nM 7.48
CHEMBL3216821 IC50 = 38.0 nM 7.42
CHEMBL3216349 IC50 = 38.0 nM 7.42
CHEMBL3217242 IC50 = 38.0 nM 7.42
CHEMBL3215933 IC50 = 39.0 nM 7.41
CHEMBL3216348 IC50 = 39.0 nM 7.41
CHEMBL2398505 IC50 = 40.0 nM 7.40
CHEMBL2398506 IC50 = 45.0 nM 7.35
CHEMBL55 PENTAMIDINE IC50 = 46.0 nM 7.34
CHEMBL3215928 IC50 = 48.0 nM 7.32
CHEMBL2398504 IC50 = 58.0 nM 7.24
CHEMBL3215925 IC50 = 71.0 nM 7.15
CHEMBL3217031 IC50 = 73.0 nM 7.14
CHEMBL3216815 IC50 = 77.0 nM 7.11
CHEMBL76 CHLOROQUINE IC50 = 125.0 nM 6.90
CHEMBL3217241 IC50 = 136.0 nM 6.87
CHEMBL3217248 IC50 = 208.0 nM 6.68
CHEMBL3217037 IC50 = 219.0 nM 6.66
CHEMBL2398508 IC50 = 486.0 nM 6.31
CHEMBL3215935 IC50 = 619.0 nM 6.21
CHEMBL3216822 IC50 = 3075.0 nM 5.51
CHEMBL2398507 IC50 = 3560.0 nM 5.45
CHEMBL3215704 IC50 = 8230.0 nM 5.08
CHEMBL3215705 IC50 = 9310.0 nM 5.03
CHEMBL3217250 IC50 > 10000.0 nM -
CHEMBL3215926 IC50 > 10000.0 nM -
CHEMBL3215692 IC50 > 10000.0 nM -