Assay Detail
Binding
CHEMBL2399572
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Displacement of [125I]IMPY from amyloid beta (1 to 42) (unknown origin) after 3 hrs by gamma counting analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 18F-labled 2-phenylindole derivatives as PET imaging probes for β-amyloid plaques.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.00 | 7.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78012 | — | — | 1 | 7.98 |
| CHEMBL2397721 | — | — | 1 | 7.55 |
| CHEMBL2397722 | — | — | 1 | 7.50 |
| CHEMBL2397724 | — | — | 1 | 7.10 |
| CHEMBL2397723 | — | — | 1 | 6.93 |
| CHEMBL2397725 | — | — | 1 | 5.99 |
| CHEMBL2397726 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78012 | — | Ki | = | 10.5 | nM | 7.98 |
| CHEMBL2397721 | — | Ki | = | 28.4 | nM | 7.55 |
| CHEMBL2397722 | — | Ki | = | 31.5 | nM | 7.50 |
| CHEMBL2397724 | — | Ki | = | 79.7 | nM | 7.10 |
| CHEMBL2397723 | — | Ki | = | 116.8 | nM | 6.93 |
| CHEMBL2397725 | — | Ki | = | 1030.1 | nM | 5.99 |
| CHEMBL2397726 | — | Ki | = | 1097.8 | nM | 5.96 |