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Assay Detail

CHEMBL2399574

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]IMPY from amyloid beta (1 to 40) (unknown origin) after 3 hrs by gamma counting analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amyloid-beta precursor protein (CHEMBL2487)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological evaluation of 18F-labled 2-phenylindole derivatives as PET imaging probes for β-amyloid plaques.
Fu H, Yu L, Cui M, Zhang J, Zhang X, Li Z, Wang X, Jia J, Yang Y, Yu P, Jia H, Liu B.
Bioorg Med Chem (2013) 21 : 3708 -3714
PubMed 23673220 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.82 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL78012 1 7.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL78012 Ki = 15.0 nM 7.82