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Assay Detail

CHEMBL2400341

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HCT116 cells assessed as cell survival at 5 to 40 uM after 7 days by crystal violet staining assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

Chromenylchalcones showing cytotoxicity on human colon cancer cell lines and in silico docking with aurora kinases.
Shin SY, Yoon H, Ahn S, Kim DW, Kim SH, Koh D, Lee YH, Lim Y.
Bioorg Med Chem (2013) 21 : 4250 -4258
PubMed 23719279 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.49 7.03

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2396883 1 7.03
CHEMBL2396880 1 6.48
CHEMBL2396885 1 6.23
CHEMBL2396876 1 5.98
CHEMBL2396884 1 5.79
CHEMBL2396882 1 5.60
CHEMBL2396879 1 5.47
CHEMBL2396881 1 5.40
CHEMBL2396877 1 5.34
CHEMBL2396878 1 5.21
CHEMBL2396888 1 5.14
CHEMBL2396889 1 5.10
CHEMBL2396891 1 4.98
CHEMBL2396886 1 4.89
CHEMBL2396887 1 4.73
CHEMBL2396890 1 4.45

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2396883 IC50 = 93.0 nM 7.03
CHEMBL2396880 IC50 = 330.0 nM 6.48
CHEMBL2396885 IC50 = 590.0 nM 6.23
CHEMBL2396876 IC50 = 1040.0 nM 5.98
CHEMBL2396884 IC50 = 1620.0 nM 5.79
CHEMBL2396882 IC50 = 2500.0 nM 5.60
CHEMBL2396879 IC50 = 3400.0 nM 5.47
CHEMBL2396881 IC50 = 3970.0 nM 5.40
CHEMBL2396877 IC50 = 4560.0 nM 5.34
CHEMBL2396878 IC50 = 6130.0 nM 5.21
CHEMBL2396888 IC50 = 7190.0 nM 5.14
CHEMBL2396889 IC50 = 7950.0 nM 5.10
CHEMBL2396891 IC50 = 10460.0 nM 4.98
CHEMBL2396886 IC50 = 12880.0 nM 4.89
CHEMBL2396887 IC50 = 18790.0 nM 4.73
CHEMBL2396890 IC50 = 35510.0 nM 4.45