Assay Detail
Binding
CHEMBL2401003
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Francisella tularensis SCHU S4 FabI R96G mutant using CrCoA as substrate by UV-vis spectrophotometric analysis in presence of non pre-equilibrated NAD+
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Francisella tularensis subsp. tularensis SCHU S4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Enoyl-[acyl-carrier-protein] reductase [NADH] (CHEMBL2150835) ↗| Type | SINGLE PROTEIN |
| Organism | Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) |
Publication
3-substituted indole inhibitors against Francisella tularensis FabI identified by structure-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.36 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL849 | TRICLOSAN | 4.0 | 1 | 7.30 |
| CHEMBL1390649 | — | — | 1 | 6.52 |
| CHEMBL1341978 | — | — | 1 | 6.10 |
| CHEMBL2398661 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL849 | TRICLOSAN | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1390649 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1341978 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2398661 | — | IC50 | = | 3000.0 | nM | 5.52 |