Assay Detail
Binding
CHEMBL2401007
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of C-terminal His6-tagged Francisella tularensis SCHU S4 FabI expressed in Escherichia coli BL21 (DE3) using CrCoA as substrate in presence of NAD+
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Francisella tularensis subsp. tularensis SCHU S4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Enoyl-[acyl-carrier-protein] reductase [NADH] (CHEMBL2150835) ↗| Type | SINGLE PROTEIN |
| Organism | Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) |
Publication
3-substituted indole inhibitors against Francisella tularensis FabI identified by structure-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 5.32 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2398661 | — | — | 1 | 5.47 |
| CHEMBL1341978 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2398661 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL1341978 | — | Ki | = | 7000.0 | nM | 5.16 |