Assay Detail
Binding
CHEMBL2401048
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human AchE using acetylthiocholine iodide as substrate incubated for 20 mins prior to substrate addition measured for 1 hr by Ellman's method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.77 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.57 |
| CHEMBL2396912 | — | — | 1 | 4.23 |
| CHEMBL2396910 | — | — | 1 | 4.22 |
| CHEMBL2396913 | — | — | 1 | 4.05 |
| CHEMBL2396914 | — | — | 1 | - |
| CHEMBL1429841 | — | — | 1 | - |
| CHEMBL2396911 | — | — | 1 | - |
| CHEMBL2396909 | — | — | 1 | - |
| CHEMBL2396908 | — | — | 1 | - |
| CHEMBL1572608 | — | — | 1 | - |
| CHEMBL2396907 | — | — | 1 | - |
| CHEMBL2396906 | — | — | 1 | - |
| CHEMBL2396905 | — | — | 1 | - |
| CHEMBL2396904 | — | — | 1 | - |
| CHEMBL2396903 | — | — | 1 | - |
| CHEMBL1376358 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL2396912 | — | IC50 | = | 59200.0 | nM | 4.23 |
| CHEMBL2396910 | — | IC50 | = | 59680.0 | nM | 4.22 |
| CHEMBL2396913 | — | IC50 | = | 88920.0 | nM | 4.05 |
| CHEMBL2396914 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1429841 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2396911 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2396909 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2396908 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1572608 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2396907 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2396906 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2396905 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2396904 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2396903 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1376358 | — | IC50 | > | 100000.0 | nM | - |