Assay Detail
Functional
CHEMBL2403962
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Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.70 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 9.82 |
| CHEMBL2401955 | — | — | 1 | 8.59 |
| CHEMBL2402024 | — | — | 1 | 8.48 |
| CHEMBL2401954 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431733 | NAMODENOSON | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL2401955 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL2402024 | — | EC50 | = | 3.33 | nM | 8.48 |
| CHEMBL2401954 | — | EC50 | = | 13.0 | nM | 7.89 |