Assay Detail
ADMET
CHEMBL2404259
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Cytotoxicity against human MALME-3 cells after 96 hrs by MTS assay in presence of aminoguanidine
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MALME-3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of polyamine transport ligands with improved metabolic stability and selectivity against specific human cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.40 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2403109 | — | — | 1 | 7.70 |
| CHEMBL557403 | — | — | 1 | 7.05 |
| CHEMBL2403112 | — | — | 1 | 6.21 |
| CHEMBL558186 | — | — | 1 | 6.16 |
| CHEMBL2403110 | — | — | 1 | 6.09 |
| CHEMBL540552 | — | — | 1 | 6.08 |
| CHEMBL2403111 | — | — | 1 | 6.00 |
| CHEMBL541654 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2403109 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL557403 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2403112 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL558186 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL2403110 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL540552 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL2403111 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL541654 | — | IC50 | = | 1270.0 | nM | 5.90 |