Assay Detail
ADMET
CHEMBL2404452
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Cytotoxicity against polyamine transport system-deficient CHO-MG cells after 48 hrs by MTS assay in presence of aminoguanidine
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cricetulus griseus |
| Cell Type | CHO-MG |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of polyamine transport ligands with improved metabolic stability and selectivity against specific human cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.71 | 4.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2403112 | — | — | 1 | 4.97 |
| CHEMBL540552 | — | — | 1 | 4.86 |
| CHEMBL557403 | — | — | 1 | 4.71 |
| CHEMBL2403109 | — | — | 1 | 4.29 |
| CHEMBL2403110 | — | — | 1 | - |
| CHEMBL541654 | — | — | 1 | - |
| CHEMBL2403111 | — | — | 1 | - |
| CHEMBL558186 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2403112 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL540552 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL557403 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL2403109 | — | IC50 | = | 51500.0 | nM | 4.29 |
| CHEMBL2403110 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL541654 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2403111 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL558186 | — | IC50 | > | 100000.0 | nM | - |