Assay Detail
Binding
CHEMBL2404651
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyluronamide from mouse adenosine A3 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.01 | 8.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2064653 | — | — | 1 | 8.91 |
| CHEMBL2402024 | — | — | 1 | 8.06 |
| CHEMBL2401954 | — | — | 1 | 8.01 |
| CHEMBL2401955 | — | — | 1 | 7.95 |
| CHEMBL2402025 | — | — | 1 | 7.15 |
| CHEMBL2089345 | — | — | 1 | 6.59 |
| CHEMBL2089346 | — | — | 1 | 6.32 |
| CHEMBL2089339 | — | — | 1 | 5.83 |
| CHEMBL2089335 | — | — | 1 | 5.82 |
| CHEMBL2402023 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2064653 | — | Ki | = | 1.23 | nM | 8.91 |
| CHEMBL2402024 | — | Ki | = | 8.75 | nM | 8.06 |
| CHEMBL2401954 | — | Ki | = | 9.68 | nM | 8.01 |
| CHEMBL2401955 | — | Ki | = | 11.3 | nM | 7.95 |
| CHEMBL2402025 | — | Ki | = | 71.1 | nM | 7.15 |
| CHEMBL2089345 | — | Ki | = | 255.0 | nM | 6.59 |
| CHEMBL2089346 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL2089339 | — | Ki | = | 1480.0 | nM | 5.83 |
| CHEMBL2089335 | — | Ki | = | 1530.0 | nM | 5.82 |
| CHEMBL2402023 | — | Ki | = | 3920.0 | nM | 5.41 |