Assay Detail
Binding
CHEMBL2404670
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Inhibition of human AChE using acetylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective inhibition of human acetylcholinesterase by xanthine derivatives: in vitro inhibition and molecular modeling investigations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.79 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.40 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.80 |
| CHEMBL1079905 | PROPENTOFYLLINE | 2.0 | 1 | 5.19 |
| CHEMBL628 | PENTOXIFYLLINE | 4.0 | 1 | 5.18 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 5.14 |
| CHEMBL1424 | XANTHINE | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL95 | TACRINE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1079905 | PROPENTOFYLLINE | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL628 | PENTOXIFYLLINE | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL113 | CAFFEINE | IC50 | = | 7250.0 | nM | 5.14 |
| CHEMBL1424 | XANTHINE | IC50 | = | 9000.0 | nM | 5.05 |