Assay Detail
Functional
CHEMBL2405181
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Antitrypanosomal activity against Trypanosoma brucei brucei assessed as parasite growth inhibition after 48 hrs by Cell-Titer Glo assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 6.03 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2401889 | — | — | 1 | 7.24 |
| CHEMBL2401902 | — | — | 1 | 6.92 |
| CHEMBL2401890 | — | — | 1 | 6.92 |
| CHEMBL2401892 | — | — | 1 | 6.92 |
| CHEMBL2401896 | — | — | 1 | 6.92 |
| CHEMBL2401891 | — | — | 1 | 6.75 |
| CHEMBL2401893 | — | — | 1 | 6.75 |
| CHEMBL2401894 | — | — | 1 | 6.70 |
| CHEMBL2401905 | — | — | 1 | 6.52 |
| CHEMBL2401895 | — | — | 1 | 6.36 |
| CHEMBL591552 | — | — | 1 | 6.04 |
| CHEMBL2401903 | — | — | 1 | 5.92 |
| CHEMBL2401907 | — | — | 1 | 4.96 |
| CHEMBL2401910 | — | — | 1 | 4.89 |
| CHEMBL2401911 | — | — | 1 | 4.75 |
| CHEMBL2401908 | — | — | 1 | 4.70 |
| CHEMBL2401909 | — | — | 1 | 4.62 |
| CHEMBL2401906 | — | — | 1 | 4.60 |
| CHEMBL2401904 | — | — | 1 | - |
| CHEMBL2401897 | — | — | 1 | - |
| CHEMBL2401898 | — | — | 1 | - |
| CHEMBL2401899 | — | — | 1 | - |
| CHEMBL2401900 | — | — | 1 | - |
| CHEMBL2401901 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2401889 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL2401902 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2401890 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2401892 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2401896 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2401891 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2401893 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2401894 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2401905 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2401895 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL591552 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL2401903 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2401907 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2401910 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2401911 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL2401908 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2401909 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL2401906 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL2401904 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL2401897 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL2401898 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL2401899 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL2401900 | — | EC50 | > | 33000.0 | nM | - |
| CHEMBL2401901 | — | EC50 | > | 33000.0 | nM | - |