Assay Detail
Binding
CHEMBL2405424
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Inhibition of GABA uptake at murine BGT-1 expressed in HEK293 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of N-substituted acyclic β-amino acids and their investigation as GABA uptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.47 | 4.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75035 | — | — | 1 | 4.51 |
| CHEMBL2403781 | — | — | 1 | 4.42 |
| CHEMBL1995111 | — | — | 1 | - |
| CHEMBL297569 | BETA-ALANINE | — | 1 | - |
| CHEMBL38686 | — | — | 1 | - |
| CHEMBL77484 | (S)-NIPECOTIC ACID | — | 1 | - |
| CHEMBL77575 | (R)-NIPECOTIC ACID | — | 1 | - |
| CHEMBL277498 | NIPECOTIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75035 | — | IC50 | = | 30902.95 | nM | 4.51 |
| CHEMBL2403781 | — | IC50 | = | 38018.94 | nM | 4.42 |
| CHEMBL1995111 | — | IC50 | = | 812830.52 | nM | - |
| CHEMBL297569 | BETA-ALANINE | IC50 | = | 331131.12 | nM | - |
| CHEMBL38686 | — | IC50 | = | 371535.23 | nM | - |
| CHEMBL77484 | (S)-NIPECOTIC ACID | IC50 | = | 758577.58 | nM | - |
| CHEMBL77575 | (R)-NIPECOTIC ACID | IC50 | = | 524807.46 | nM | - |
| CHEMBL277498 | NIPECOTIC ACID | IC50 | = | 794328.23 | nM | - |