Assay Detail
Functional
CHEMBL2405440
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Cytotoxicity against human HCT116 cells assessed as cell viability after 48 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Superior anticancer activity of halogenated chalcones and flavonols over the natural flavonol quercetin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.94 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2403796 | — | — | 1 | 5.34 |
| CHEMBL270935 | — | — | 1 | 5.17 |
| CHEMBL2403795 | — | — | 1 | 5.12 |
| CHEMBL272006 | — | — | 1 | 5.09 |
| CHEMBL492739 | — | — | 1 | 4.96 |
| CHEMBL2403794 | — | — | 1 | 4.89 |
| CHEMBL250867 | — | — | 1 | 4.88 |
| CHEMBL2403800 | — | — | 1 | 4.84 |
| CHEMBL2401759 | — | — | 1 | 4.84 |
| CHEMBL89988 | — | — | 1 | 4.72 |
| CHEMBL1963387 | — | — | 1 | 4.69 |
| CHEMBL241861 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2403796 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL270935 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL2403795 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL272006 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL492739 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL2403794 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL250867 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL2403800 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL2401759 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL89988 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL1963387 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL241861 | — | IC50 | = | 20900.0 | nM | 4.68 |