Assay Detail
Binding
CHEMBL2405975
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Inhibition of p38 MAPK-mediated TNFalpha production in LPS-induced human whole blood preincubated for 5 mins prior to LPS-treatment measured after 6 hrs by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.54 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2402001 | — | — | 1 | 9.14 |
| CHEMBL2401997 | — | — | 1 | 8.77 |
| CHEMBL2401999 | — | — | 1 | 8.22 |
| CHEMBL2401998 | — | — | 1 | 8.02 |
| CHEMBL2402000 | — | — | 1 | - |
| CHEMBL2401996 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2402001 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL2401997 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL2401999 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2401998 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL2402000 | — | IC50 | - | — | - | |
| CHEMBL2401996 | — | IC50 | - | — | - |