Assay Detail
Functional
CHEMBL2406005
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Cytotoxicity against human HCT116 cells expressing wild type p53 assessed as growth inhibition by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.76 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2402737 | IDASANUTLIN | 3.0 | 1 | 8.00 |
| CHEMBL2402734 | — | — | 1 | 7.40 |
| CHEMBL2402732 | — | — | 1 | 7.05 |
| CHEMBL2402731 | — | — | 1 | 7.05 |
| CHEMBL2402735 | — | — | 1 | 6.85 |
| CHEMBL2402733 | — | — | 1 | 6.85 |
| CHEMBL2402736 | — | — | 1 | 6.70 |
| CHEMBL2402730 | — | — | 1 | 6.39 |
| CHEMBL2402729 | — | — | 1 | 5.85 |
| CHEMBL2402573 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2402737 | IDASANUTLIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2402734 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2402732 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2402731 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2402735 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2402733 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2402736 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2402730 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2402729 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL2402573 | — | IC50 | = | 3400.0 | nM | 5.47 |