Assay Detail
Binding
CHEMBL2406149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of acetylcholinesterase (unknown origin) using acetylcholine iodide as substrate preincubated for 15 mins prior to substrate addition by spectrophotometric analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New bioactive dihydrofuranocoumarins from the roots of the Tunisian Ferula lutea (Poir.) Maire.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.62 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 8.54 |
| CHEMBL416 | METHOXSALEN | 4.0 | 1 | 6.12 |
| CHEMBL164660 | PSORALEN | 1.0 | 1 | 5.19 |
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | - |
| CHEMBL51628 | UMBELLIFERONE | — | 1 | - |
| CHEMBL1443379 | — | — | 1 | - |
| CHEMBL2402007 | (-)-PRANTSCHIMGIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL416 | METHOXSALEN | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL164660 | PSORALEN | IC50 | = | 6480.0 | nM | 5.19 |
| CHEMBL145 | CAFFEIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL51628 | UMBELLIFERONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL1443379 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2402007 | (-)-PRANTSCHIMGIN | IC50 | > | 100000.0 | nM | - |