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Assay Detail

CHEMBL2406370

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HCT116 cells after 5 days by Alamar Blue assay
ChEMBL ↗
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Benzofused hydroxamic acids: useful fragments for the preparation of histone deacetylase inhibitors. Part 1: hit identification.
Marastoni E, Bartoli S, Berettoni M, Cipollone A, Ettorre A, Fincham CI, Mauro S, Paris M, Porcelloni M, Bigioni M, Binaschi M, Nardelli F, Parlani M, Maggi CA, Fattori D.
Bioorg Med Chem Lett (2013) 23 : 4091 -4095
PubMed 23768910 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 43 6.04 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2403479 — — 1 7.16
CHEMBL247183 — — 1 7.00
CHEMBL2403464 — — 1 6.96
CHEMBL245364 — — 1 6.60
CHEMBL2403474 — — 1 6.50
CHEMBL2403472 — — 1 6.47
CHEMBL2403458 — — 1 6.32
CHEMBL247384 — — 1 6.31
CHEMBL2403466 — — 1 6.30
CHEMBL2403470 — — 1 6.30
CHEMBL2403468 — — 1 6.26
CHEMBL2403467 — — 1 6.22
CHEMBL2403480 — — 1 6.14
CHEMBL2403471 — — 1 6.11
CHEMBL2403476 — — 1 6.08
CHEMBL394888 — — 1 5.92
CHEMBL245749 — — 1 5.89
CHEMBL247184 — — 1 5.89
CHEMBL2403478 — — 1 5.89
CHEMBL2403481 — — 1 5.85
CHEMBL2403477 — — 1 5.77
CHEMBL2403462 — — 1 5.75
CHEMBL2403469 — — 1 5.62
CHEMBL247382 — — 1 5.58
CHEMBL2403460 — — 1 5.52
CHEMBL2403475 — — 1 5.47
CHEMBL2403473 — — 1 5.30
CHEMBL2403461 — — 1 5.07
CHEMBL2403459 — — 1 4.77
CHEMBL2403463 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2403479 — IC50 = 70.0 nM 7.16
CHEMBL247183 — IC50 = 100.0 nM 7.00
CHEMBL2403464 — IC50 = 110.0 nM 6.96
CHEMBL245364 — IC50 = 250.0 nM 6.60
CHEMBL2403474 — IC50 = 320.0 nM 6.50
CHEMBL2403472 — IC50 = 340.0 nM 6.47
CHEMBL2403458 — IC50 = 480.0 nM 6.32
CHEMBL247384 — IC50 = 490.0 nM 6.31
CHEMBL2403466 — IC50 = 500.0 nM 6.30
CHEMBL2403470 — IC50 = 500.0 nM 6.30
CHEMBL2403468 — IC50 = 550.0 nM 6.26
CHEMBL2403467 — IC50 = 600.0 nM 6.22
CHEMBL2403480 — IC50 = 730.0 nM 6.14
CHEMBL2403471 — IC50 = 770.0 nM 6.11
CHEMBL2403476 — IC50 = 830.0 nM 6.08
CHEMBL394888 — IC50 = 1200.0 nM 5.92
CHEMBL245749 — IC50 = 1300.0 nM 5.89
CHEMBL247184 — IC50 = 1300.0 nM 5.89
CHEMBL2403478 — IC50 = 1300.0 nM 5.89
CHEMBL2403481 — IC50 = 1400.0 nM 5.85
CHEMBL2403477 — IC50 = 1700.0 nM 5.77
CHEMBL2403462 — IC50 = 1800.0 nM 5.75
CHEMBL2403469 — IC50 = 2400.0 nM 5.62
CHEMBL247382 — IC50 = 2600.0 nM 5.58
CHEMBL2403460 — IC50 = 3000.0 nM 5.52
CHEMBL2403475 — IC50 = 3400.0 nM 5.47
CHEMBL2403473 — IC50 = 5000.0 nM 5.30
CHEMBL2403461 — IC50 = 8600.0 nM 5.07
CHEMBL2403459 — IC50 = 17000.0 nM 4.77
CHEMBL2403486 — IC50 - — -
CHEMBL2403485 — IC50 - — -
CHEMBL394386 — IC50 - — -
CHEMBL2403484 — IC50 - — -
CHEMBL245554 — IC50 - — -
CHEMBL245357 — IC50 - — -
CHEMBL2403454 — IC50 - — -
CHEMBL2403465 — IC50 - — -
CHEMBL2403455 — IC50 - — -
CHEMBL2403456 — IC50 - — -
CHEMBL2403457 — IC50 - — -
CHEMBL2403483 — IC50 - — -
CHEMBL2403482 — IC50 - — -
CHEMBL2403463 — IC50 - — -