Assay Detail
Functional
CHEMBL2406643
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Relaxtant activity in guinea pig K+-depolarized ileum longitudinal smooth muscle assessed as inhibition of calcium-induced contraction
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.84 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL558 | MEXILETINE | 4.0 | 1 | 5.07 |
| CHEMBL2401842 | — | — | 1 | 4.87 |
| CHEMBL2018453 | — | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL558 | MEXILETINE | IC50 | = | 8520.0 | nM | 5.07 |
| CHEMBL2401842 | — | IC50 | = | 13580.0 | nM | 4.87 |
| CHEMBL2018453 | — | IC50 | = | 25830.0 | nM | 4.59 |