Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL613680 Target Snapshot

Ileum · TISSUE · Cavia porcellus

Back to Search Search this target Browse approvals Evidence Card
501Compounds
191Assays
9Approved Drugs
349.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace
Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Ileum as ChEMBL target CHEMBL613680. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Ileum
TISSUE · Cavia porcellus
As of 2026-09-14
ChEMBL target ID
CHEMBL613680
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Ileum still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameIleum
Target TypeTISSUE
OrganismCavia porcellus
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelIleum
UniProt AccessionN/A

Ileum

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Ileum.

Review nameIleum
OrganismCavia porcellus
Clinical Profile

Clinical Phase Distribution

9
Approved
1
Phase III
1
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50250.0
EC5072.0
KD27.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL11 8.9 Kd 1.259 Approved
CHEMBL193 8.82 EC50 1.5 Approved
CHEMBL193 8.82 IC50 1.5 Approved
CHEMBL517712 8.69 Kd 2.042 Approved
CHEMBL2381470 8.64 IC50 2.3 Preclinical
CHEMBL316446 8.06 IC50 8.73 Preclinical
CHEMBL5076581 8.04 IC50 9.21 Preclinical
CHEMBL333357 7.95 IC50 11.3 Preclinical
CHEMBL5085104 7.93 IC50 11.8 Preclinical
CHEMBL3230381 7.6 IC50 25.0 Preclinical
Distribution

pChEMBL Value Distribution

40
5.0
47
5.5
21
6.0
17
6.5
7
7.0
5
7.5
3
8.0
5
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

DILTIAZEM
CHEMBL23
Approved 1982
Properties Compare Identifier
NIFEDIPINE
CHEMBL193
Approved 1981
Properties Compare Identifier
ATROPINE
CHEMBL517712
Approved 1960
Properties Compare Identifier
IMIPRAMINE
CHEMBL11
Approved 1959
Properties Compare Identifier
CHLORPROMAZINE
CHEMBL71
Approved 1957
Properties Compare Identifier
Assay Landscape

Assay Landscape

191
Total Assays
164
Tested Compounds
3
Assay Types
Functional — 166 assays, 164 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 166 164 5.7
Toxicity — 15 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 15 0 —
ADME — 10 assays, 27 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 10 27 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine