Assay Detail
Functional
CHEMBL2406871
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Antitrypanosomal activity against blood stream form of Trypanosoma brucei brucei
17
Total Activities
15
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibition of rhodesain as a novel therapeutic modality for human African trypanosomiasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| ED50 | 10 | 7.33 | 7.75 |
| IC50 | 5 | 5.03 | 5.44 |
| MIC | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406405 | — | — | 2 | 7.75 |
| CHEMBL177914 | — | — | 2 | 7.35 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 6.89 |
| CHEMBL128221 | — | — | 1 | 5.44 |
| CHEMBL426774 | — | — | 1 | 5.32 |
| CHEMBL2179950 | — | — | 1 | 5.21 |
| CHEMBL2402202 | — | — | 1 | 4.68 |
| CHEMBL2402203 | — | — | 1 | 4.51 |
| CHEMBL604079 | — | — | 1 | - |
| CHEMBL604281 | — | — | 1 | - |
| CHEMBL327624 | — | — | 1 | - |
| CHEMBL594719 | — | — | 1 | - |
| CHEMBL2402190 | — | — | 1 | - |
| CHEMBL604078 | — | — | 1 | - |
| CHEMBL91704 | K-777 | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406405 | — | ED50 | = | 18.0 | nM | 7.75 |
| CHEMBL177914 | — | ED50 | = | 45.0 | nM | 7.35 |
| CHEMBL265502 | SURAMIN | ED50 | = | 130.0 | nM | 6.89 |
| CHEMBL128221 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL426774 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2179950 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL2402202 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL2402203 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL604079 | — | ED50 | - | — | - | |
| CHEMBL604281 | — | ED50 | - | — | - | |
| CHEMBL177914 | — | MIC | = | 100000.0 | nM | - |
| CHEMBL327624 | — | ED50 | = | 5.6 | uM | - |
| CHEMBL594719 | — | ED50 | = | 1.4 | uM | - |
| CHEMBL2402190 | — | ED50 | = | 1.2 | uM | - |
| CHEMBL604078 | — | ED50 | = | 1.1 | uM | - |
| CHEMBL91704 | K-777 | ED50 | = | 0.9 | uM | - |
| CHEMBL406405 | — | MIC | = | 10000.0 | nM | - |