Assay Detail
Functional
CHEMBL2409977
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Human immunodeficiency virus 1 LAI infected in PHA-stimulated human PBMC
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Adenosine Dioxolane Nucleoside Phosphoramidates as Antiviral Agents for Human Immunodeficiency and Hepatitis B Viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.37 | 9.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2408218 | — | — | 1 | 9.25 |
| CHEMBL2408219 | — | — | 1 | 8.48 |
| CHEMBL2408214 | — | — | 1 | 7.07 |
| CHEMBL2408221 | — | — | 1 | 6.47 |
| CHEMBL458876 | AMDOXOVIR | 2.0 | 1 | 6.40 |
| CHEMBL2408222 | — | — | 1 | 6.38 |
| CHEMBL2408215 | — | — | 1 | 6.11 |
| CHEMBL38860 | — | — | 1 | 5.70 |
| CHEMBL2408217 | — | — | 1 | 5.16 |
| CHEMBL2408216 | — | — | 1 | 4.96 |
| CHEMBL2408213 | — | — | 1 | 4.04 |
| CHEMBL2408220 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2408218 | — | EC50 | = | 0.56 | nM | 9.25 |
| CHEMBL2408219 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL2408214 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL2408221 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL458876 | AMDOXOVIR | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2408222 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2408215 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL38860 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2408217 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2408216 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2408213 | — | EC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL2408220 | — | EC50 | > | 100000.0 | nM | - |