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Assay Detail

CHEMBL2410189

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant HDAC4 by Michaelis-Menten equation analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histone deacetylase 4 (CHEMBL3524)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors.
Ononye SN, VanHeyst MD, Oblak EZ, Zhou W, Ammar M, Anderson AC, Wright DL.
ACS Med Chem Lett (2013) 4 : 757 -761
PubMed 24900743 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 5.26 6.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2408245 1 6.09
CHEMBL2408247 1 6.00
CHEMBL2408246 1 5.21
CHEMBL2408243 1 5.08
CHEMBL2408242 1 4.96
CHEMBL2408244 1 4.95
CHEMBL2408248 1 4.93
CHEMBL99 TRICHOSTATIN 1.0 1 4.84
CHEMBL48310 HINOKITIOL 1 -
CHEMBL2408241 1 -
CHEMBL2408240 1 -
CHEMBL2408239 1 -
CHEMBL2408238 1 -
CHEMBL2408237 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2408245 Ki = 806.13 nM 6.09
CHEMBL2408247 Ki = 990.23 nM 6.00
CHEMBL2408246 Ki = 6115.0 nM 5.21
CHEMBL2408243 Ki = 8361.0 nM 5.08
CHEMBL2408242 Ki = 10860.0 nM 4.96
CHEMBL2408244 Ki = 11204.0 nM 4.95
CHEMBL2408248 Ki = 11641.0 nM 4.93
CHEMBL99 TRICHOSTATIN Ki = 14547.0 nM 4.84
CHEMBL48310 HINOKITIOL Ki > 20000.0 nM -
CHEMBL2408241 Ki > 20000.0 nM -
CHEMBL2408240 Ki > 20000.0 nM -
CHEMBL2408239 Ki > 20000.0 nM -
CHEMBL2408238 Ki > 20000.0 nM -
CHEMBL2408237 Ki > 20000.0 nM -