Assay Detail
Binding
CHEMBL2411274
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine kidney intestinal alkaline phosphatase using p-NPP as substrate treated 10 mins before substrate addition measured after 30 mins by spectrophotometric assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Alkaline phosphatase, tissue-nonspecific isozyme (CHEMBL2406894) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 4.74 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2408701 | — | — | 1 | 6.89 |
| CHEMBL2408705 | — | — | 1 | 6.60 |
| CHEMBL1814391 | — | — | 1 | 5.17 |
| CHEMBL1814400 | — | — | 1 | 4.78 |
| CHEMBL1814397 | — | — | 1 | 4.75 |
| CHEMBL2408704 | — | — | 1 | 4.68 |
| CHEMBL2408560 | — | — | 1 | 4.66 |
| CHEMBL2408698 | — | — | 1 | 4.64 |
| CHEMBL1814399 | — | — | 1 | 4.58 |
| CHEMBL2408699 | — | — | 1 | 4.57 |
| CHEMBL2408702 | — | — | 1 | 4.54 |
| CHEMBL2408703 | — | — | 1 | 4.54 |
| CHEMBL2408697 | — | — | 1 | 4.42 |
| CHEMBL1814396 | — | — | 1 | 4.39 |
| CHEMBL2408700 | — | — | 1 | 4.37 |
| CHEMBL1814398 | — | — | 1 | 4.36 |
| CHEMBL1814393 | — | — | 1 | 4.32 |
| CHEMBL1814395 | — | — | 1 | 4.22 |
| CHEMBL1814394 | — | — | 1 | 4.20 |
| CHEMBL2408706 | — | — | 1 | 4.13 |
| CHEMBL1814392 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2408701 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL2408705 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL1814391 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL1814400 | — | Ki | = | 16800.0 | nM | 4.78 |
| CHEMBL1814397 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL2408704 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL2408560 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL2408698 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL1814399 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL2408699 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL2408702 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL2408703 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL2408697 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL1814396 | — | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL2408700 | — | Ki | = | 43000.0 | nM | 4.37 |
| CHEMBL1814398 | — | Ki | = | 44000.0 | nM | 4.36 |
| CHEMBL1814393 | — | Ki | = | 48000.0 | nM | 4.32 |
| CHEMBL1814395 | — | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL1814394 | — | Ki | = | 63000.0 | nM | 4.20 |
| CHEMBL2408706 | — | Ki | = | 74000.0 | nM | 4.13 |
| CHEMBL1814392 | — | Ki | = | 220000.0 | nM | - |