Assay Detail
Binding
CHEMBL2411323
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FGFR1 (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISA
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Naphthalimides exhibit in vitro antiproliferative and antiangiogenic activities by inhibiting both topoisomerase II (topo II) and receptor tyrosine kinases (RTKs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.50 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502835 | NINTEDANIB | 4.0 | 1 | 7.22 |
| CHEMBL598852 | — | — | 1 | 4.74 |
| CHEMBL598022 | — | — | 1 | 4.54 |
| CHEMBL2407635 | — | — | 1 | - |
| CHEMBL2407519 | — | — | 1 | - |
| CHEMBL2407518 | — | — | 1 | - |
| CHEMBL2407517 | — | — | 1 | - |
| CHEMBL2407516 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502835 | NINTEDANIB | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL598852 | — | IC50 | = | 18060.0 | nM | 4.74 |
| CHEMBL598022 | — | IC50 | = | 28790.0 | nM | 4.54 |
| CHEMBL2407635 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2407519 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2407518 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2407517 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2407516 | — | IC50 | > | 100000.0 | nM | - |