Assay Detail
Binding
CHEMBL2411324
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGFRbeta (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISA
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Naphthalimides exhibit in vitro antiproliferative and antiangiogenic activities by inhibiting both topoisomerase II (topo II) and receptor tyrosine kinases (RTKs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.70 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502835 | NINTEDANIB | 4.0 | 1 | 8.70 |
| CHEMBL2407635 | — | — | 1 | - |
| CHEMBL598022 | — | — | 1 | - |
| CHEMBL598852 | — | — | 1 | - |
| CHEMBL2407519 | — | — | 1 | - |
| CHEMBL2407518 | — | — | 1 | - |
| CHEMBL2407517 | — | — | 1 | - |
| CHEMBL2407516 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502835 | NINTEDANIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2407635 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL598022 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL598852 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2407519 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2407518 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2407517 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2407516 | — | IC50 | > | 100000.0 | nM | - |