Assay Detail
ADMET
CHEMBL2411331
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Cytotoxicity against human LO2 cells after 72 hrs by sulforhodamine B assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | L02 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Naphthalimides exhibit in vitro antiproliferative and antiangiogenic activities by inhibiting both topoisomerase II (topo II) and receptor tyrosine kinases (RTKs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.87 | 4.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2407516 | — | — | 1 | 4.87 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 4.86 |
| CHEMBL2407635 | — | — | 1 | - |
| CHEMBL598022 | — | — | 1 | - |
| CHEMBL598852 | — | — | 1 | - |
| CHEMBL2407519 | — | — | 1 | - |
| CHEMBL2407518 | — | — | 1 | - |
| CHEMBL2407517 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2407516 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL2407635 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL598022 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL598852 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2407519 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2407518 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2407517 | — | IC50 | > | 50000.0 | nM | - |