Assay Detail
Binding
CHEMBL2411729
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of amyloid beta (1-42) self-mediated aggregation (unknown origin) after 5 days by thioflavin T fluorescence method
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.95 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2408099 | — | — | 1 | 5.66 |
| CHEMBL2408101 | — | — | 1 | 5.50 |
| CHEMBL2407101 | — | — | 1 | 5.24 |
| CHEMBL2408100 | — | — | 1 | 5.23 |
| CHEMBL2408263 | — | — | 1 | 5.14 |
| CHEMBL2408093 | — | — | 1 | 5.11 |
| CHEMBL2408262 | — | — | 1 | 5.08 |
| CHEMBL229907 | — | — | 1 | 5.08 |
| CHEMBL260867 | — | — | 1 | 5.01 |
| CHEMBL2408264 | — | — | 1 | 5.00 |
| CHEMBL258752 | — | — | 1 | 4.99 |
| CHEMBL2408092 | — | — | 1 | 4.98 |
| CHEMBL2408091 | — | — | 1 | 4.96 |
| CHEMBL2408095 | — | — | 1 | 4.90 |
| CHEMBL2408265 | — | — | 1 | 4.88 |
| CHEMBL2408098 | — | — | 1 | 4.84 |
| CHEMBL2408104 | — | — | 1 | 4.80 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 4.80 |
| CHEMBL2408102 | — | — | 1 | 4.75 |
| CHEMBL2408097 | — | — | 1 | 4.73 |
| CHEMBL2408094 | — | — | 1 | 4.72 |
| CHEMBL2408106 | — | — | 1 | 4.72 |
| CHEMBL2408105 | — | — | 1 | 4.72 |
| CHEMBL129795 | ISOLIQUIRITIGENIN | — | 1 | 4.71 |
| CHEMBL2408261 | — | — | 1 | 4.70 |
| CHEMBL2408103 | — | — | 1 | 4.70 |
| CHEMBL2408096 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2408099 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2408101 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2407101 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL2408100 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL2408263 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2408093 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL2408262 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL229907 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL260867 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL2408264 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL258752 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL2408092 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL2408091 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL2408095 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL2408265 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL2408098 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL2408104 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL165 | RESVERATROL | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL2408102 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL2408097 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL2408094 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL2408106 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL2408105 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL129795 | ISOLIQUIRITIGENIN | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL2408261 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL2408103 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL2408096 | — | IC50 | = | 23800.0 | nM | 4.62 |