Assay Detail
ADMET
CHEMBL2411784
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Cytotoxicity against human KB cells after 72 hrs by Alamar blue assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, Antiplasmodial Activity, and β-Hematin Inhibition of Hydroxypyridone-Chloroquine Hybrids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.92 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 9.15 |
| CHEMBL2407832 | — | — | 1 | 5.40 |
| CHEMBL2407845 | — | — | 1 | 5.40 |
| CHEMBL3217247 | — | — | 1 | 5.16 |
| CHEMBL2407843 | — | — | 1 | 5.05 |
| CHEMBL2407841 | — | — | 1 | 4.82 |
| CHEMBL2407835 | — | — | 1 | 4.57 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.47 |
| CHEMBL2407833 | — | — | 1 | 4.36 |
| CHEMBL2407834 | — | — | 1 | 4.33 |
| CHEMBL2407839 | — | — | 1 | 4.29 |
| CHEMBL2407838 | — | — | 1 | 4.27 |
| CHEMBL2407848 | — | — | 1 | 4.26 |
| CHEMBL2407840 | — | — | 1 | 4.17 |
| CHEMBL2407849 | — | — | 1 | 4.12 |
| CHEMBL2335237 | — | — | 1 | - |
| CHEMBL2407842 | — | — | 1 | - |
| CHEMBL2407844 | — | — | 1 | - |
| CHEMBL2407837 | — | — | 1 | - |
| CHEMBL2407847 | — | — | 1 | - |
| CHEMBL2335235 | — | — | 1 | - |
| CHEMBL2335236 | — | — | 1 | - |
| CHEMBL2407836 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL2407832 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2407845 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3217247 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2407843 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL2407841 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2407835 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL2407833 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL2407834 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL2407839 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL2407838 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL2407848 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL2407840 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL2407849 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL2335237 | — | IC50 | - | — | - | |
| CHEMBL2407842 | — | IC50 | = | 119000.0 | nM | - |
| CHEMBL2407844 | — | IC50 | = | 158000.0 | nM | - |
| CHEMBL2407837 | — | IC50 | - | — | - | |
| CHEMBL2407847 | — | IC50 | - | — | - | |
| CHEMBL2335235 | — | IC50 | - | — | - | |
| CHEMBL2335236 | — | IC50 | = | 185000.0 | nM | - |
| CHEMBL2407836 | — | IC50 | - | — | - |