Assay Detail
Functional
CHEMBL2411786
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as parasite survival after 2 days by YOYO-1 staining-based flow cytometric analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, Antiplasmodial Activity, and β-Hematin Inhibition of Hydroxypyridone-Chloroquine Hybrids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.47 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2407845 | — | — | 1 | 7.70 |
| CHEMBL2407832 | — | — | 1 | 7.16 |
| CHEMBL2335236 | — | — | 1 | 7.10 |
| CHEMBL2407834 | — | — | 1 | 7.05 |
| CHEMBL2407833 | — | — | 1 | 7.05 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.00 |
| CHEMBL2407843 | — | — | 1 | 7.00 |
| CHEMBL2407849 | — | — | 1 | 6.80 |
| CHEMBL2407837 | — | — | 1 | 6.68 |
| CHEMBL2407836 | — | — | 1 | 6.66 |
| CHEMBL2335237 | — | — | 1 | 6.55 |
| CHEMBL2407844 | — | — | 1 | 6.41 |
| CHEMBL2407848 | — | — | 1 | 6.27 |
| CHEMBL2407835 | — | — | 1 | 6.12 |
| CHEMBL2407842 | — | — | 1 | 5.95 |
| CHEMBL2407847 | — | — | 1 | 5.91 |
| CHEMBL2407840 | — | — | 1 | 5.67 |
| CHEMBL2407841 | — | — | 1 | 5.63 |
| CHEMBL2407839 | — | — | 1 | 5.59 |
| CHEMBL2407838 | — | — | 1 | 5.00 |
| CHEMBL3217247 | — | — | 1 | - |
| CHEMBL2335235 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2407845 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2407832 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2335236 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2407834 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2407833 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2407843 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2407849 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2407837 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2407836 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2335237 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2407844 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL2407848 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2407835 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL2407842 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL2407847 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL2407840 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL2407841 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL2407839 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL2407838 | — | IC50 | = | 9930.0 | nM | 5.00 |
| CHEMBL3217247 | — | IC50 | - | — | - | |
| CHEMBL2335235 | — | IC50 | - | — | - |