Assay Detail
Binding
CHEMBL2412191
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from rat mu opioid receptor expressed in human/mouse HN9.10 cell membranes after 3 hrs by liquid scintillation counting analysis
18
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chiral Effect of a Phe Residue in Position 3 of the Dmt(1)-L(or D)-Tic(2) Analogues on Opioid Functional Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.13 | 9.35 |
| IC50 | 7 | 7.94 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2408014 | — | — | 2 | 9.35 |
| CHEMBL538700 | — | — | 1 | 8.92 |
| CHEMBL2408016 | — | — | 2 | 8.72 |
| CHEMBL2408010 | — | — | 1 | 8.42 |
| CHEMBL2408018 | — | — | 2 | 8.19 |
| CHEMBL2408011 | — | — | 2 | 8.02 |
| CHEMBL2408017 | — | — | 2 | 7.92 |
| CHEMBL2408015 | — | — | 2 | 7.85 |
| CHEMBL2408012 | — | — | 2 | 7.82 |
| CHEMBL2408013 | — | — | 1 | 7.66 |
| CHEMBL2408019 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2408014 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL2408014 | — | IC50 | = | 0.955 | nM | 9.02 |
| CHEMBL538700 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL2408016 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL2408010 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL2408016 | — | IC50 | = | 4.074 | nM | 8.39 |
| CHEMBL2408018 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL2408011 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL2408017 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL2408018 | — | IC50 | = | 13.49 | nM | 7.87 |
| CHEMBL2408015 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL2408012 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL2408011 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL2408013 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL2408017 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL2408015 | — | IC50 | = | 28.84 | nM | 7.54 |
| CHEMBL2408012 | — | IC50 | = | 32.36 | nM | 7.49 |
| CHEMBL2408019 | — | Ki | = | 280.0 | nM | 6.55 |