Assay Detail
Functional
CHEMBL2412686
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Cytotoxicity against human 786 cells after 48 hrs by sulforhodamine B assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.72 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.48 |
| CHEMBL2409553 | — | — | 1 | 6.17 |
| CHEMBL2409552 | — | — | 1 | 5.91 |
| CHEMBL2409551 | — | — | 1 | 5.77 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.30 |
| CHEMBL2409555 | — | — | 1 | 4.68 |
| CHEMBL1978637 | — | — | 1 | - |
| CHEMBL2409554 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2409553 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL2409552 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL2409551 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2409555 | — | IC50 | = | 20690.0 | nM | 4.68 |
| CHEMBL1978637 | — | IC50 | - | — | - | |
| CHEMBL2409554 | — | IC50 | = | 111670.0 | nM | - |